The Amipurimycin and Miharamycin Biosynthetic Gene Clusters: Unraveling the Origins of 2-Aminopurinyl Peptidyl Nucleoside Antibiotics

Peptidyl nucleoside antibiotics (PNAs) are a diverse class of natural products with promising biomedical activities. These compounds have tripartite structures composed of a core saccharide, a nucleobase, and one or more amino acids. In particular, amipurimycin and the miharamycins are novel 2-amino...

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Bibliografiske detaljer
Udgivet i:J Am Chem Soc
Main Authors: Romo, Anthony J., Shiraishi, Taro, Ikeuchi, Hideo, Lin, Geng-Min, Geng, Yujie, Lee, Yu-Hsuan, Liem, Priscilla H., Ma, Tianlu, Ogasawara, Yasushi, Shin-ya, Kazuo, Nishiyama, Makoto, Kuzuyama, Tomohisa, Liu, Hung-wen
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774755/
https://ncbi.nlm.nih.gov/pubmed/31150226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b03021
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