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Apparent Genetic Rescue of Adult Shank3 Exon 21 Insertion Mutation Mice Tempered by Appropriate Control Experiments

SHANK3 (ProSAP2) is among the most common genes mutated in autism spectrum disorders (ASD) and is the causative gene in Phelan–McDermid syndrome (PMS). We performed genetic rescue of Shank3 mutant phenotypes in adult mice expressing a Shank3 exon 21 insertion mutation (Shank3(G)). We used a tamoxife...

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Bibliografiske detaljer
Udgivet i:eNeuro
Main Authors: Speed, Haley E., Kouser, Mehreen, Xuan, Zhong, Liu, Shunan, Duong, Anne, Powell, Craig M.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774147/
https://ncbi.nlm.nih.gov/pubmed/31451607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0317-19.2019
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