Apparent Genetic Rescue of Adult Shank3 Exon 21 Insertion Mutation Mice Tempered by Appropriate Control Experiments

SHANK3 (ProSAP2) is among the most common genes mutated in autism spectrum disorders (ASD) and is the causative gene in Phelan–McDermid syndrome (PMS). We performed genetic rescue of Shank3 mutant phenotypes in adult mice expressing a Shank3 exon 21 insertion mutation (Shank3(G)). We used a tamoxife...

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Detalhes bibliográficos
Publicado no:eNeuro
Main Authors: Speed, Haley E., Kouser, Mehreen, Xuan, Zhong, Liu, Shunan, Duong, Anne, Powell, Craig M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2019
Assuntos:
New Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774147/
https://ncbi.nlm.nih.gov/pubmed/31451607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0317-19.2019
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