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Functionalization of 4-bromobenzo[c][2,7]naphthyridine via regioselective direct ring metalation. A novel approach to analogues of pyridoacridine alkaloids

Readily available 4-bromobenzo[c][2,7]naphthyridine undergoes regioselective direct ring metalation at C-5 with TMPMgCl∙LiCl at −40 °C. Quenching with various electrophiles gives a broad range of 5-substituted products, which are building blocks for the synthesis of heterocyclic natural products and...

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Detalhes bibliográficos
Publicado no:Beilstein J Org Chem
Main Authors: Melzer, Benedikt C, Plodek, Alois, Bracher, Franz
Formato: Artigo
Idioma:Inglês
Publicado em: Beilstein-Institut 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774065/
https://ncbi.nlm.nih.gov/pubmed/31598182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.15.222
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