Reducing EphA4 before disease onset does not affect survival in a mouse model of Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons resulting in severe neurological symptoms. Previous findings of our lab suggested that the axonal guidance tyrosine-kinase receptor EphA4 is an ALS disease-modifying gene. Reduction of EphA4 from developmen...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Rué, Laura, Timmers, Mieke, Lenaerts, Annette, Smolders, Silke, Poppe, Lindsay, de Boer, Antina, Van Den Bosch, Ludo, Van Damme, Philip, Robberecht, Wim, Lemmens, Robin
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773754/
https://ncbi.nlm.nih.gov/pubmed/31575928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50615-0
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