mTORC1-mediated polarization of M1 macrophages and their accumulation in the liver correlate with immunopathology in fatal ehrlichiosis

A polarized macrophage response into inflammatory (M1) or regenerative/anti-inflammatory (M2) phenotypes is critical in host response to multiple intracellular bacterial infections. Ehrlichia is an obligate Gram-negative intracellular bacterium that causes human monocytic ehrlichiosis (HME): a febri...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Haloul, Mohamed, Oliveira, Edson R. A., Kader, Muhamuda, Wells, Jakob Z., Tominello, Tyler R., El Andaloussi, Abdeljabar, Yates, Cecelia C., Ismail, Nahed
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773708/
https://ncbi.nlm.nih.gov/pubmed/31575880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50320-y
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