Neuronal Apoptosis by Apolipoprotein E4 through Low-Density Lipoprotein Receptor-Related Protein and Heterotrimeric GTPases

The ε4 genotype of apolipoprotein E (apoE4) is the most established predisposing factor in Alzheimer's disease (AD); however, it remains unclear how apoE4 contributes to the pathophysiology. Here, we report that the apoE4 protein (ApoE4) evokes apoptosis in neuronal cells through the low-densit...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Hashimoto, Yuichi, Jiang, Hong, Niikura, Takako, Ito, Yuko, Hagiwara, Akari, Umezawa, Kazuo, Abe, Yoichiro, Murayama, Yoshitake, Nishimoto, Ikuo
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2000
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ARTICLE
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773153/
https://ncbi.nlm.nih.gov/pubmed/11069947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-22-08401.2000
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