The Polyglutamine Expansion in Spinocerebellar Ataxia Type 6 Causes a β Subunit-Specific Enhanced Activation of P/Q-Type Calcium Channels in Xenopus Oocytes

Spinocerebellar ataxia type 6 (SCA6) is a dominantly inherited degenerative disorder of the cerebellum characterized by nearly selective and progressive death of Purkinje cells. The underlying mutation in SCA6 consists of an expansion of a trinucleotide CAG repeat in the 3′ region of the gene, CACNA...

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Publié dans:J Neurosci
Auteurs principaux: Restituito, Sophie, Thompson, Randall M., Eliet, Jacob, Raike, Robert S., Riedl, Maureen, Charnet, Pierre, Gomez, Christopher M.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2000
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772973/
https://ncbi.nlm.nih.gov/pubmed/10964945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-17-06394.2000
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