Suppressed Injury-Induced Rise in Spinal Prostaglandin E(2) Production and Reduced Early Thermal Hyperalgesia in iNOS-Deficient Mice

It is widely accepted that peripheral injury increases spinal inducible cyclooxygenase (COX-2) expression and prostaglandin E(2) (PGE(2)) formation as key mediators of nociceptive sensitization. Here, we used inducible nitric oxide synthase (iNOS) gene-deficient (iNOS−/−) mice to determine the contr...

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Publié dans:J Neurosci
Auteurs principaux: Gühring, Hans, Görig, Manfred, Ates, Mehmet, Coste, Ovidiu, Zeilhofer, Hanns Ulrich, Pahl, Andreas, Rehse, Klaus, Brune, Kay
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2000
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772960/
https://ncbi.nlm.nih.gov/pubmed/10964977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-17-06714.2000
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