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Homocysteine Elicits a DNA Damage Response in Neurons That Promotes Apoptosis and Hypersensitivity to Excitotoxicity

Elevated plasma levels of the sulfur-containing amino acid homocysteine increase the risk for atherosclerosis, stroke, and possibly Alzheimer's disease, but the underlying mechanisms are unknown. We now report that homocysteine induces apoptosis in rat hippocampal neurons. DNA strand breaks and...

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Publicado en:J Neurosci
Autores principales: Kruman, Inna I., Culmsee, Carsten, Chan, Sic L., Kruman, Yuri, Guo, Zhihong, Penix, LaRoy, Mattson, Mark P.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2000
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772815/
https://ncbi.nlm.nih.gov/pubmed/10995836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-18-06920.2000
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