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Homocysteine Elicits a DNA Damage Response in Neurons That Promotes Apoptosis and Hypersensitivity to Excitotoxicity

Elevated plasma levels of the sulfur-containing amino acid homocysteine increase the risk for atherosclerosis, stroke, and possibly Alzheimer's disease, but the underlying mechanisms are unknown. We now report that homocysteine induces apoptosis in rat hippocampal neurons. DNA strand breaks and...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Kruman, Inna I., Culmsee, Carsten, Chan, Sic L., Kruman, Yuri, Guo, Zhihong, Penix, LaRoy, Mattson, Mark P.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772815/
https://ncbi.nlm.nih.gov/pubmed/10995836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-18-06920.2000
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