Tumor Necrosis Factor Receptor-Associated Factor 6 (TRAF6) Deficiency Results in Exencephaly and Is Required for Apoptosis within the Developing CNS

Tumor necrosis factor receptor-associated factors (TRAFs) are adaptor proteins important in mediating intracellular signaling. We report here that targeted deletion of traf6 greatly increases the frequency of failure of neural tube closure and exencephaly in traf6 (−/−) mice. The penetrance of this...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Lomaga, Mark A., Henderson, Jeffrey T., Elia, Andrew J., Robertson, Jennifer, Noyce, Ryan S., Yeh, Wen-Chen, Mak, Tak W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2000
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772765/
https://ncbi.nlm.nih.gov/pubmed/11007897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-19-07384.2000
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