Functional Consequences of Reduction in NMDA Receptor Glycine Affinity in Mice Carrying Targeted Point Mutations in the Glycine Binding Site

We have used site-directed mutagenesis in conjunction with homologous recombination to generate two mouse lines carrying point mutations in the glycine binding site of the NMDAR1 subunit (Grin1). Glycine concentration–response curves from acutely dissociated hippocampal neurons revealed a 5- and 86-...

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Publicado no:J Neurosci
Main Authors: Kew, James N. C., Koester, Anja, Moreau, Jean-Luc, Jenck, Francois, Ouagazzal, Abdel-Mouttalib, Mutel, Vincent, Richards, J. Grayson, Trube, Gerhard, Fischer, Guenther, Montkowski, Alexandra, Hundt, Wolfgang, Reinscheid, Rainer K., Pauly-Evers, Meike, Kemp, John A., Bluethmann, Horst
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2000
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772652/
https://ncbi.nlm.nih.gov/pubmed/10818139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-11-04037.2000
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