Functional Consequences of Reduction in NMDA Receptor Glycine Affinity in Mice Carrying Targeted Point Mutations in the Glycine Binding Site

We have used site-directed mutagenesis in conjunction with homologous recombination to generate two mouse lines carrying point mutations in the glycine binding site of the NMDAR1 subunit (Grin1). Glycine concentration–response curves from acutely dissociated hippocampal neurons revealed a 5- and 86-...

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Gepubliceerd in:J Neurosci
Hoofdauteurs: Kew, James N. C., Koester, Anja, Moreau, Jean-Luc, Jenck, Francois, Ouagazzal, Abdel-Mouttalib, Mutel, Vincent, Richards, J. Grayson, Trube, Gerhard, Fischer, Guenther, Montkowski, Alexandra, Hundt, Wolfgang, Reinscheid, Rainer K., Pauly-Evers, Meike, Kemp, John A., Bluethmann, Horst
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Society for Neuroscience 2000
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772652/
https://ncbi.nlm.nih.gov/pubmed/10818139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-11-04037.2000
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