Delayed Mitochondrial Dysfunction in Excitotoxic Neuron Death: Cytochrome c Release and a Secondary Increase in Superoxide Production

An increased production of superoxide has been shown to mediate glutamate-induced neuron death. We monitored intracellular superoxide production of hippocampal neurons during and after exposure to the glutamate receptor agonist NMDA (300 μm). During a 30 min NMDA exposure, intracellular superoxide p...

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Vydáno v:J Neurosci
Hlavní autoři: Luetjens, C. Marc, Bui, Nguyen Truc, Sengpiel, Bernd, Münstermann, Gudrun, Poppe, Monika, Krohn, Aaron J., Bauerbach, Elke, Krieglstein, Josef, Prehn, Jochen H. M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2000
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772544/
https://ncbi.nlm.nih.gov/pubmed/10908611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-15-05715.2000
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