Abnormal Synaptic Plasticity and Impaired Spatial Cognition in Mice Transgenic for Exon 1 of the Human Huntington's Disease Mutation

Huntington's disease (HD) is an autosomal dominant progressive and fatal neurodegenerative brain disorder caused by an expanded CAG/polyglutamine repeat in the coding region of the gene. Presymptomatic Huntington's disease patients often exhibit cognitive deficits before the onset of class...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Murphy, Kerry P. S. J., Carter, Rebecca J., Lione, Lisa A., Mangiarini, Laura, Mahal, Amarbirpal, Bates, Gillian P., Dunnett, Stephen B., Morton, A. Jennifer
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2000
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772265/
https://ncbi.nlm.nih.gov/pubmed/10864968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-13-05115.2000
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