Hippocampal Abnormalities and Enhanced Excitability in a Murine Model of Human Lissencephaly

Human cortical heterotopia and neuronal migration disorders result in epilepsy; however, the precise mechanisms remain elusive. Here we demonstrate severe neuronal dysplasia and heterotopia throughout the granule cell and pyramidal cell layers of mice containing a heterozygous deletion of Lis1, a mo...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Fleck, Mark W., Hirotsune, Shinji, Gambello, Michael J., Phillips-Tansey, Emily, Suares, Gregory, Mervis, Ronald F., Wynshaw-Boris, Anthony, McBain, Chris J.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2000
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772237/
https://ncbi.nlm.nih.gov/pubmed/10729324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-07-02439.2000
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