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Inverting Small Molecule–Protein Recognition by the Fluorine Gauche Effect: Selectivity Regulated by Multiple H→F Bioisosterism
Fluorinated motifs have a venerable history in drug discovery, but as C(sp(3))−F‐rich 3D scaffolds appear with increasing frequency, the effect of multiple bioisosteric changes on molecular recognition requires elucidation. Herein we demonstrate that installation of a 1,3,5‐stereotriad, in the subst...
שמור ב:
| הוצא לאור ב: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
John Wiley and Sons Inc.
2019
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6771710/ https://ncbi.nlm.nih.gov/pubmed/31157945 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201905452 |
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