Inverting Small Molecule–Protein Recognition by the Fluorine Gauche Effect: Selectivity Regulated by Multiple H→F Bioisosterism

Fluorinated motifs have a venerable history in drug discovery, but as C(sp(3))−F‐rich 3D scaffolds appear with increasing frequency, the effect of multiple bioisosteric changes on molecular recognition requires elucidation. Herein we demonstrate that installation of a 1,3,5‐stereotriad, in the subst...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Bentler, Patrick, Bergander, Klaus, Daniliuc, Constantin G., Mück‐Lichtenfeld, Christian, Jumde, Ravindra P., Hirsch, Anna K. H., Gilmour, Ryan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6771710/
https://ncbi.nlm.nih.gov/pubmed/31157945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201905452
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