Transcriptional alterations in glioma result primarily from DNA methylation–independent mechanisms

In cancer cells, aberrant DNA methylation is commonly associated with transcriptional alterations, including silencing of tumor suppressor genes. However, multiple epigenetic mechanisms, including polycomb repressive marks, contribute to gene deregulation in cancer. To dissect the relative contribut...

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Veröffentlicht in:Genome Res
Hauptverfasser: Court, Franck, Le Boiteux, Elisa, Fogli, Anne, Müller-Barthélémy, Mélanie, Vaurs-Barrière, Catherine, Chautard, Emmanuel, Pereira, Bruno, Biau, Julian, Kemeny, Jean-Louis, Khalil, Toufic, Karayan-Tapon, Lucie, Verrelle, Pierre, Arnaud, Philippe
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6771409/
https://ncbi.nlm.nih.gov/pubmed/31533980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.249219.119
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