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Mechanisms of Connexin-Related Lymphedema: A Critical Role for Cx45, but not Cx43 or Cx47, in the Entrainment of Spontaneous Lymphatic Contractions
RATIONALE: Mutations in GJC2 and GJA1, encoding connexins (Cxs) 47 and 43 respectively, are linked to lymphedema, but the underlying mechanisms are unknown. Because efficient lymph transport relies on the coordinated contractions of lymphatic muscle cells (LMCs) and the electrical coupling of those...
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| Udgivet i: | Circ Res |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6771293/ https://ncbi.nlm.nih.gov/pubmed/30355030 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.117.312576 |
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