Mechanisms of Connexin-Related Lymphedema: A Critical Role for Cx45, but not Cx43 or Cx47, in the Entrainment of Spontaneous Lymphatic Contractions

RATIONALE: Mutations in GJC2 and GJA1, encoding connexins (Cxs) 47 and 43 respectively, are linked to lymphedema, but the underlying mechanisms are unknown. Because efficient lymph transport relies on the coordinated contractions of lymphatic muscle cells (LMCs) and the electrical coupling of those...

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Publicado no:Circ Res
Main Authors: Castorena-Gonzalez, Jorge A., Zawieja, Scott D., Li, Min, Srinivasan, R. Sathish, Simon, Alexander M., de Wit, Cor, de la Torre, Roger, Martinez-Lemus, Luis A., Hennig, Grant W., Davis, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6771293/
https://ncbi.nlm.nih.gov/pubmed/30355030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.117.312576
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