Generation of hepatic spheroids using human hepatocyte-derived liver progenitor-like cells for hepatotoxicity screening

Rationale: The idiosyncratic drug-induced liver injury (iDILI) is a major cause of acute liver injury and a key challenge in late-stage drug development. Individual heterogeneity is considered to be an essential factor of iDILI. However, few in vitro model can predict heterogeneity in iDILI. We have...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Wang, Zhenyu, Li, Weijian, Jing, Hongshu, Ding, Ming, Fu, Gongbo, Yuan, Tianjie, Huang, Weijian, Dai, Mengjun, Tang, Dan, Zeng, Min, Chen, Yi, Zhang, Hongdan, Zhu, Xuejing, Peng, Yuan, Li, Qigen, Yu, Wei-Feng, Yan, He-Xin, Zhai, Bo
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6771233/
https://ncbi.nlm.nih.gov/pubmed/31588244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.34520
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