Utility of B-13 Progenitor-Derived Hepatocytes in Hepatotoxicity and Genotoxicity Studies

AR42J-B-13 (B-13) cells form hepatocyte-like (B-13/H) cells in response to glucocorticoid treatment. To establish its utility in toxicity and genotoxicity screening, cytochrome P450 (CYP) induction, susceptibility to toxins, and transporter gene expression were examined. Conversion to B-13/H cells r...

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Autori principali: Probert, Philip M. E., Chung, Git W., Cockell, Simon J., Agius, Loranne, Mosesso, Pasquale, White, Steven A., Oakley, Fiona, Brown, Colin D. A., Wright, Matthew C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908725/
https://ncbi.nlm.nih.gov/pubmed/24235770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kft258
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