Progenitor-derived hepatocyte-like (B-13/H) cells metabolise 1′-hydroxyestragole to a genotoxic species via a SULT2B1-dependent mechanism

Rat B-13 progenitor cells are readily converted into functional hepatocyte-like B-13/H cells capable of phase I cytochrome P450-dependent activation of pro-carcinogens and induction of DNA damage. The aim of the present study was to investigate whether the cells are also capable of Phase II sulphotr...

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Publicado en:Toxicol Lett
Autores principales: Probert, Philip M., Palmer, Jeremy M., Alhusainy, Wasma, Amer, Aimen O., Rietjens, Ivonne M.C.M., White, Steven A., Jones, David E., Wright, Matthew C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729325/
https://ncbi.nlm.nih.gov/pubmed/26739637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2015.12.010
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