A decade of clinical development of PARP inhibitors in perspective

Genomic instability is a hallmark of cancer, and often is the result of altered DNA repair capacities in tumour cells. DNA damage repair defects are common in different cancer types; these alterations can also induce tumour-specific vulnerabilities that can be exploited therapeutically. In 2009, a f...

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Bibliographische Detailangaben
Veröffentlicht in:Ann Oncol
Hauptverfasser: Mateo, J, Lord, C J, Serra, V, Tutt, A, Balmaña, J, Castroviejo-Bermejo, M, Cruz, C, Oaknin, A, Kaye, S B, de Bono, J S
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6771225/
https://ncbi.nlm.nih.gov/pubmed/31218365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdz192
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