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CRISPR/Cas9 Editing of the Polyomavirus Tumor Antigens Inhibits Merkel Cell Carcinoma Growth In Vitro

Merkel cell carcinoma (MCC) is an aggressive type of skin cancer whose main causative agent is Merkel cell polyomavirus (MCPyV). MCPyV is integrated into the genome of the tumor cells in most MCCs. Virus-positive tumor cells constitutively express two viral oncoproteins that promote cell growth: the...

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Publicat a:Cancers (Basel)
Autors principals: Temblador, Arturo, Topalis, Dimitrios, Andrei, Graciela, Snoeck, Robert
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6770690/
https://ncbi.nlm.nih.gov/pubmed/31466237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11091260
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