Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer’s disease

Systematic epistasis analyses in multifactorial disorders are an important step to better characterize complex genetic risk structures. We conducted a hypothesis-free sex-stratified genome-wide screening for epistasis contributing to Alzheimer’s disease (AD) susceptibility. We identified a statistic...

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Veröffentlicht in:Neurobiol Aging
Hauptverfasser: Gusareva, Elena S., Twizere, Jean-Claude, Sleegers, Kristel, Dourlen, Pierre, Abisambra, Jose F., Meier, Shelby, Cloyd, Ryan, Weiss, Blaine, Dermaut, Bart, Bessonov, Kyrylo, van der Lee, Sven J., Carrasquillo, Minerva M., Katsumata, Yuriko, Cherkaoui, Majid, Asselbergh, Bob, Ikram, M. Arfan, Mayeux, Richard, Farrer, Lindsay A., Haines, Jonathan L., Pericak-Vance, Margaret A., Schellenberg, Gerard D., Sims, Rebecca, Williams, Julie, Amouyel, Philippe, van Duijn, Cornelia M., Ertekin-Taner, Nilüfer, Van Broeckhoven, Christine, Dequiedt, Franck, Fardo, David W., Lambert, Jean-Charles, Van Steen, Kristel
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6769421/
https://ncbi.nlm.nih.gov/pubmed/30201328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2018.08.001
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