The Gene Encoding Nicastrin, a Major γ-Secretase Component, Modifies Risk for Familial Early-Onset Alzheimer Disease in a Dutch Population-Based Sample

Nicastrin regulates γ-secretase cleavage of the amyloid precursor protein by forming complexes with presenilins, in which most mutations causing familial early-onset Alzheimer disease (EOAD) have been found. The gene encoding nicastrin (NCSTN) maps to 1q23, a region that has been linked and associat...

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Bibliografiske detaljer
Main Authors: Dermaut, Bart, Theuns, Jessie, Sleegers, Kristel, Hasegawa, Hiroshi, Van den Broeck, Marleen, Vennekens, Krist'l, Corsmit, Ellen, St. George-Hyslop, Peter, Cruts, Marc, van Duijn, Cornelia M., Van Broeckhoven, Christine
Format: Artigo
Sprog:Inglês
Udgivet: The American Society of Human Genetics 2002
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC379144/
https://ncbi.nlm.nih.gov/pubmed/11992262
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