The Gene Encoding Nicastrin, a Major γ-Secretase Component, Modifies Risk for Familial Early-Onset Alzheimer Disease in a Dutch Population-Based Sample

Nicastrin regulates γ-secretase cleavage of the amyloid precursor protein by forming complexes with presenilins, in which most mutations causing familial early-onset Alzheimer disease (EOAD) have been found. The gene encoding nicastrin (NCSTN) maps to 1q23, a region that has been linked and associat...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Dermaut, Bart, Theuns, Jessie, Sleegers, Kristel, Hasegawa, Hiroshi, Van den Broeck, Marleen, Vennekens, Krist'l, Corsmit, Ellen, St. George-Hyslop, Peter, Cruts, Marc, van Duijn, Cornelia M., Van Broeckhoven, Christine
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Human Genetics 2002
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC379144/
https://ncbi.nlm.nih.gov/pubmed/11992262
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados