ATRX loss induces telomere dysfunction and necessitates induction of alternative lengthening of telomeres during human cell immortalization

Loss of the histone H3.3‐specific chaperone component ATRX or its partner DAXX frequently occurs in human cancers that employ alternative lengthening of telomeres (ALT) for chromosomal end protection, yet the underlying mechanism remains unclear. Here, we report that ATRX/DAXX does not serve as an i...

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Bibliographic Details
Published in:EMBO J
Main Authors: Li, Fei, Deng, Zhong, Zhang, Ling, Wu, Caizhi, Jin, Ying, Hwang, Inah, Vladimirova, Olga, Xu, Libo, Yang, Lynnie, Lu, Bin, Dheekollu, Javaraju, Li, Jian‐Yi, Feng, Hua, Hu, Jian, Vakoc, Christopher R, Ying, Haoqiang, Paik, Jihye, Lieberman, Paul M, Zheng, Hongwu
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6769380/
https://ncbi.nlm.nih.gov/pubmed/31454099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201796659
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