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Population pharmacokinetics of fedratinib in patients with myelofibrosis, polycythemia vera, and essential thrombocythemia

PURPOSE: Fedratinib (SAR302503, TG101348) is an orally administered Janus kinase (JAK) 2-selective inhibitor that is being developed for the treatment of patients with myelofibrosis (MF). The objectives of this analysis were to develop a population pharmacokinetic (PK) model to characterize fedratin...

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Bibliografske podrobnosti
izdano v:Cancer Chemother Pharmacol
Main Authors: Ogasawara, Ken, Zhou, Simon, Krishna, Gopal, Palmisano, Maria, Li, Yan
Format: Artigo
Jezik:Inglês
Izdano: Springer Berlin Heidelberg 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6768916/
https://ncbi.nlm.nih.gov/pubmed/31444617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-019-03929-9
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