TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis

High-throughput DNA sequence analysis was used to screen for TET2 mutations in bone marrow-derived DNA from 239 patients with BCR-ABL-negative myeloproliferative neoplasms (MPNs). Thirty-two mutations (19 frameshift, 10 nonsense, 3 missense; mostly involving exons 4 and 12) were identified for an ov...

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Vydáno v:Leukemia
Hlavní autoři: Tefferi, A, Pardanani, A, Lim, K-H, Abdel-Wahab, O, Lasho, TL, Patel, J, Gangat, N, Finke, CM, Schwager, S, Mullally, A, Li, C-Y, Hanson, CA, Mesa, R, Bernard, O, Delhommeau, F, Vainchenker, W, Gilliland, DG, Levine, RL
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4654629/
https://ncbi.nlm.nih.gov/pubmed/19262601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2009.47
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