Targeted genomic CRISPR-Cas9 screen identifies MAP4K4 as essential for glioblastoma invasion

Among high-grade brain tumors, glioblastoma is particularly difficult to treat, in part due to its highly infiltrative nature which contributes to the malignant phenotype and high mortality in patients. In order to better understand the signaling pathways underlying glioblastoma invasion, we perform...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Prolo, Laura M., Li, Amy, Owen, Scott F., Parker, Jonathon J., Foshay, Kara, Nitta, Ryan T., Morgens, David W., Bolin, Sara, Wilson, Christy M., Vega L, Johana C. M., Luo, Emily J., Nwagbo, Gigi, Waziri, Allen, Li, Gordon, Reimer, Richard J., Bassik, Michael C., Grant, Gerald A.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6768851/
https://ncbi.nlm.nih.gov/pubmed/31570734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50160-w
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