Differential Regulation of T Cell Immunity and Tolerance by Stromal Laminin Expressed in the Lymph Node

BACKGROUND: Stromal laminins α4 and α5 are differentially regulated in transplant tolerance and immunity, respectively, resulting in altered T cell trafficking. We hypothesized laminins directly regulated T cell activation and polarization. METHODS: Human and mouse CD4 T cells were activated in Th1,...

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Veröffentlicht in:Transplantation
Hauptverfasser: Simon, Thomas, Li, Lushen, Wagner, Chelsea, Zhang, Tianshu, Saxena, Vikas, Brinkman, C. Colin, Tostanoski, Lisa H., Ostrand-Rosenberg, Suzanne, Jewell, Chris, Shea-Donohue, Terez, Hippen, Keli, Blazar, Bruce, Abdi, Reza, Bromberg, Jonathan S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6768765/
https://ncbi.nlm.nih.gov/pubmed/31343575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0000000000002774
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