The lymph node stromal laminin α5 shapes alloimmunity

Lymph node stromal cells (LNSCs) regulate immunity through constructing lymphocyte niches. LNSC-produced laminin α5 (Lama5) regulates CD4(+) T cells but the underlying mechanisms of its functions are poorly understood. Here we show that depleting Lama5 in LNSCs resulted in decreased Lama5 protein in...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Li, Lushen, Shirkey, Marina W., Zhang, Tianshu, Xiong, Yanbao, Piao, Wenji, Saxena, Vikas, Paluskievicz, Christina, Lee, Young, Toney, Nicholas, Cerel, Benjamin M., Li, Qinshan, Simon, Thomas, Smith, Kyle D., Hippen, Keli L., Blazar, Bruce R., Abdi, Reza, Bromberg, Jonathan S.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190966/
https://ncbi.nlm.nih.gov/pubmed/32017712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI135099
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