Development of a practical synthesis of etravirine via a microwave-promoted amination

BACKGROUND: Etravirine (ETV) was approved as the second generation drug for use in individuals infected with HIV-1 in 2008 by the U.S. FDA with its unique antiviral activity, high specificity, and low toxicity. However, there are some shortcomings of the existing synthetic routes, such as the long r...

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Bibliographic Details
Published in:Chem Cent J
Main Authors: Feng, Da, Wei, Fenju, Wang, Zhao, Kang, Dongwei, Zhan, Peng, Liu, Xinyong
Format: Artigo
Language:Inglês
Published: Springer International Publishing 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6768033/
https://ncbi.nlm.nih.gov/pubmed/30569261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13065-018-0504-4
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