Reverse pharmacophore mapping and molecular docking studies for discovery of GTPase HRas as promising drug target for bis-pyrimidine derivatives

BACKGROUND: Pyrimidine is an important pharmacophore in the field of medicinal chemistry and exhibit a broad spectrum of biological potentials. A study was carried out to identify the target protein of potent bis-pyrimidine derivatives using reverse docking program. PharmMapper, a robust online tool...

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Publicado en:Chem Cent J
Autores principales: Kumar, Sanjiv, Singh, Jagbir, Narasimhan, Balasubramanian, Shah, Syed Adnan Ali, Lim, Siong Meng, Ramasamy, Kalavathy, Mani, Vasudevan
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer International Publishing 2018
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6768019/
https://ncbi.nlm.nih.gov/pubmed/30345469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13065-018-0475-5
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