Molecular docking, synthesis and biological significance of pyrimidine analogues as prospective antimicrobial and antiproliferative agents

Abstract Pyrimidine nucleus is a significant pharmacophore that exhibited excellent pharmacological activities. A series of pyrimidine scaffolds was synthesized and its chemical structures were confirmed by physicochemical and spectral analysis. The synthesized compounds were evaluated for their ant...

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Bibliografiske detaljer
Main Authors: Sanjiv Kumar, Archana Kaushik, Balasubramanian Narasimhan, Syed Adnan Ali Shah, Siong Meng Lim, Kalavathy Ramasamy, Vasudevan Mani
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2019-07-01
Serier:BMC Chemistry
Fag:
Pyrimidine analogues
Antibacterial activity
Anticancer activity
Docking study
Online adgang:http://link.springer.com/article/10.1186/s13065-019-0601-z
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