A small peptide antagonist of the Fas receptor inhibits neuroinflammation and prevents axon degeneration and retinal ganglion cell death in an inducible mouse model of glaucoma

BACKGROUND: Glaucoma is a complex, multifactorial disease where apoptosis, microglia activation, and inflammation have been linked to the death of retinal ganglion cells (RGCs) and axon degeneration. We demonstrated previously that FasL-Fas signaling was required for axon degeneration and death of R...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Neuroinflammation
Prif Awduron: Krishnan, Anitha, Kocab, Andrew J., Zacks, David N., Marshak-Rothstein, Ann, Gregory-Ksander, Meredith
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2019
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6767653/
https://ncbi.nlm.nih.gov/pubmed/31570110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1576-3
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