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Site Selective Antibody-Oligonucleotide Conjugation via Microbial Transglutaminase
Nucleic Acid Therapeutics (NATs), including siRNAs and AntiSense Oligonucleotides (ASOs), have great potential to drug the undruggable genome. Targeting siRNAs and ASOs to specific cell types of interest has driven dramatic improvement in efficacy and reduction in toxicity. Indeed, conjugation of tr...
Enregistré dans:
| Publié dans: | Molecules |
|---|---|
| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
MDPI
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6767100/ https://ncbi.nlm.nih.gov/pubmed/31509944 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24183287 |
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