Perivascular CD73(+) cells attenuate inflammation and interstitial fibrosis in the kidney microenvironment

Progressive tubulointerstitial fibrosis may occur after acute kidney injury due to persistent inflammation. Purinergic signaling by 5′-ectonucleotidase, CD73, an enzyme that converts AMP to adenosine on the extracellular surface, can suppress inflammation. The role of CD73 in progressive kidney fibr...

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Detalhes bibliográficos
Publicado no:Am J Physiol Renal Physiol
Main Authors: Perry, Heather M., Görldt, Nicole, Sung, Sun-sang J., Huang, Liping, Rudnicka, Kinga P., Encarnacion, Iain M., Bajwa, Amandeep, Tanaka, Shinji, Poudel, Nabin, Yao, Junlan, Rosin, Diane L., Schrader, Jürgen, Okusa, Mark D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6766625/
https://ncbi.nlm.nih.gov/pubmed/31364375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00243.2019
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