CRISPR/Cas9 Knockout of Bak Mediates Bax Translocation to Mitochondria in response to TNFα/CHX-induced Apoptosis

TNFα/CHX-induced apoptosis is dependent on caspase-8 activation and regulated by Bcl-2. However, the specific participants and precise mechanisms underlying this apoptotic pathway are poorly understood. The proapoptotic proteins Bak and Bax—members of the Bcl-2 family—are essential for the functioni...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Biomed Res Int
मुख्य लेखकों: Zhang, Jingtian, Niu, Han, Zhao, Zhizhuang Joe, Fu, Xueqi, Wang, Yuxiang, Zhang, Xu, Zhang, Fuqiang, Zeng, Linlin
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Hindawi 2019
विषय:
Research Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6766168/
https://ncbi.nlm.nih.gov/pubmed/31637258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/9071297
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