Nonlinear Mixed‐Effects Model Development and Simulation Using nlmixr and Related R Open‐Source Packages

nlmixr is a free and open‐source R package for fitting nonlinear pharmacokinetic (PK), pharmacodynamic (PD), joint PK‐PD, and quantitative systems pharmacology mixed‐effects models. Currently, nlmixr is capable of fitting both traditional compartmental PK models as well as more complex models implem...

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Bibliografske podrobnosti
izdano v:CPT Pharmacometrics Syst Pharmacol
Main Authors: Fidler, Matthew, Wilkins, Justin J., Hooijmaijers, Richard, Post, Teun M., Schoemaker, Rik, Trame, Mirjam N., Xiong, Yuan, Wang, Wenping
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2019
Teme:
Tutorial
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765694/
https://ncbi.nlm.nih.gov/pubmed/31207186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12445
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