Nonlinear Mixed‐Effects Model Development and Simulation Using nlmixr and Related R Open‐Source Packages

nlmixr is a free and open‐source R package for fitting nonlinear pharmacokinetic (PK), pharmacodynamic (PD), joint PK‐PD, and quantitative systems pharmacology mixed‐effects models. Currently, nlmixr is capable of fitting both traditional compartmental PK models as well as more complex models implem...

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Publicado en:CPT Pharmacometrics Syst Pharmacol
Autores principales: Fidler, Matthew, Wilkins, Justin J., Hooijmaijers, Richard, Post, Teun M., Schoemaker, Rik, Trame, Mirjam N., Xiong, Yuan, Wang, Wenping
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2019
Materias:
Tutorial
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765694/
https://ncbi.nlm.nih.gov/pubmed/31207186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12445
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