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Joint profiling of DNA methylation and chromatin architecture in single cells
We report a method, Methyl-HiC, which captures the chromosome conformation and DNA methylome together in a cell. We use it to reveal coordinated DNA methylation status between distal genomic segments that are in spatial proximity in the nucleus and delineate heterogeneity of both the chromatin archi...
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| I publikationen: | Nat Methods |
|---|---|
| Huvudupphovsmän: | , , , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2019
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6765429/ https://ncbi.nlm.nih.gov/pubmed/31384045 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41592-019-0502-z |
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