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An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity
TRiC/CCT assists the folding of ∼10% of cytosolic proteins through an ATP-driven conformational cycle and is essential in maintaining protein homeostasis. Here, we determined an ensemble of cryo-electron microscopy (cryo-EM) structures of yeast TRiC at various nucleotide concentrations, with 4 open-...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6765261/ https://ncbi.nlm.nih.gov/pubmed/31492816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903976116 |
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