An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity

TRiC/CCT assists the folding of ∼10% of cytosolic proteins through an ATP-driven conformational cycle and is essential in maintaining protein homeostasis. Here, we determined an ensemble of cryo-electron microscopy (cryo-EM) structures of yeast TRiC at various nucleotide concentrations, with 4 open-...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Jin, Mingliang, Han, Wenyu, Liu, Caixuan, Zang, Yunxiang, Li, Jiawei, Wang, Fangfang, Wang, Yanxing, Cong, Yao
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2019
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765261/
https://ncbi.nlm.nih.gov/pubmed/31492816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903976116
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