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A new class of disordered elements controls DNA replication through initiator self-assembly
The initiation of DNA replication in metazoans occurs at thousands of chromosomal sites known as origins. At each origin, the Origin Recognition Complex (ORC), Cdc6, and Cdt1 co-assemble to load the Mcm2-7 replicative helicase onto chromatin. Current replication models envisage a linear arrangement...
में बचाया:
| में प्रकाशित: | eLife |
|---|---|
| मुख्य लेखकों: | , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
eLife Sciences Publications, Ltd
2019
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6764820/ https://ncbi.nlm.nih.gov/pubmed/31560342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.48562 |
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