A new class of disordered elements controls DNA replication through initiator self-assembly

The initiation of DNA replication in metazoans occurs at thousands of chromosomal sites known as origins. At each origin, the Origin Recognition Complex (ORC), Cdc6, and Cdt1 co-assemble to load the Mcm2-7 replicative helicase onto chromatin. Current replication models envisage a linear arrangement...

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Detalles Bibliográficos
Publicado en:eLife
Autores principales: Parker, Matthew W, Bell, Maren, Mir, Mustafa, Kao, Jonchee A, Darzacq, Xavier, Botchan, Michael R, Berger, James M
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764820/
https://ncbi.nlm.nih.gov/pubmed/31560342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.48562
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