A new class of disordered elements controls DNA replication through initiator self-assembly

The initiation of DNA replication in metazoans occurs at thousands of chromosomal sites known as origins. At each origin, the Origin Recognition Complex (ORC), Cdc6, and Cdt1 co-assemble to load the Mcm2-7 replicative helicase onto chromatin. Current replication models envisage a linear arrangement...

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Pubblicato in:eLife
Autori principali: Parker, Matthew W, Bell, Maren, Mir, Mustafa, Kao, Jonchee A, Darzacq, Xavier, Botchan, Michael R, Berger, James M
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2019
Soggetti:
Biochemistry and Chemical Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764820/
https://ncbi.nlm.nih.gov/pubmed/31560342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.48562
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