A new class of disordered elements controls DNA replication through initiator self-assembly

The initiation of DNA replication in metazoans occurs at thousands of chromosomal sites known as origins. At each origin, the Origin Recognition Complex (ORC), Cdc6, and Cdt1 co-assemble to load the Mcm2-7 replicative helicase onto chromatin. Current replication models envisage a linear arrangement...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Parker, Matthew W, Bell, Maren, Mir, Mustafa, Kao, Jonchee A, Darzacq, Xavier, Botchan, Michael R, Berger, James M
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2019
Pynciau:
Biochemistry and Chemical Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764820/
https://ncbi.nlm.nih.gov/pubmed/31560342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.48562
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