Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration

In neurodegenerative diseases, debris of dead neurons are thought to trigger glia-mediated neuroinflammation, thus increasing neuronal death. Here, we show that expression of neurotoxic proteins associated with these diseases in microglia alone is sufficient to trigger death of naïve neurons directl...

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Udgivet i:Nat Neurosci
Main Authors: Joshi, Amit U., Minhas, Paras S., Liddelow, Shane A., Haileselassie, Bereketeab, Andreasson, Katrin I., Dorn II, Gerald W., Mochly-Rosen, Daria
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764589/
https://ncbi.nlm.nih.gov/pubmed/31551592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-019-0486-0
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