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Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration
In neurodegenerative diseases, debris of dead neurons are thought to trigger glia-mediated neuroinflammation, thus increasing neuronal death. Here, we show that expression of neurotoxic proteins associated with these diseases in microglia alone is sufficient to trigger death of naïve neurons directl...
Gorde:
| Argitaratua izan da: | Nat Neurosci |
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| Egile Nagusiak: | , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2019
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6764589/ https://ncbi.nlm.nih.gov/pubmed/31551592 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-019-0486-0 |
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